Biological markers can be either 1)state or 2)trait markers (endophenotype is type 2)).

It’s in the causal pathway from gene to mental illness diseases.

Ex) neurophysiological, biochemical, endocrinological, neuroanatomical, or neuropsychological.

It helps, 1) target etiology and mechanisms; 2) identify persons who are at increased risk(for appropriate intervention); 3)classifications of clinical phenotypes; 4) differentiate possible biological subtypes,

It lies in the causal pathway (not as a result of the disease), and independent(observed in subjects who are at risk but not currently symptomatic)

Source: Koenen, et al. A life course approach to mental disorders.


#epidemiology #psychiatric_epi #biomarker #intergeneration #Study

Published by sunjaejung

Epidemiologist/Psychiatric Epidemiologist/ Preventive Medicine Specialist/ Medical Doctor

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: